Chigusa Morizane Selected Research

resminostat

1/2021	A randomized, double-blind, phase II study of oral histone deacetylase inhibitor resminostat plus S-1 versus placebo plus S-1 in biliary tract cancers previously treated with gemcitabine plus platinum-based chemotherapy.
1/2019	Phase I study of resminostat, an HDAC inhibitor, combined with S-1 in patients with pre-treated biliary tract or pancreatic cancer.

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Chigusa Morizane Research Topics

Disease

59	Neoplasms (Cancer) 05/2024 - 09/2004
42	Pancreatic Neoplasms (Pancreatic Cancer) 05/2024 - 01/2005
28	Biliary Tract Neoplasms (Biliary Tract Cancer) 04/2024 - 01/2003
26	Hepatocellular Carcinoma (Hepatoma) 09/2022 - 02/2005
10	Neoplasm Metastasis (Metastasis) 12/2023 - 12/2007
10	Adenocarcinoma 01/2023 - 01/2005
9	Neutropenia 10/2022 - 02/2005
8	Neuroendocrine Tumors (Neuroendocrine Tumor) 01/2022 - 10/2013
7	Neuroendocrine Carcinoma 10/2022 - 04/2010
6	Thrombocytopenia (Thrombopenia) 06/2017 - 02/2005
5	Pathologic Constriction (Stenosis) 03/2024 - 01/2008
5	Disease Progression 01/2023 - 04/2014
5	Cholangiocarcinoma 01/2023 - 07/2008
5	Carcinoma (Carcinomatosis) 10/2020 - 08/2005
5	Leukopenia 06/2017 - 02/2005
3	Fistula 09/2023 - 04/2022
3	Stomatitis 01/2023 - 10/2012
3	Exanthema (Rash) 01/2019 - 10/2012
2	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 04/2024 - 12/2020
2	Gastric Outlet Obstruction 03/2024 - 02/2022
2	Lymphatic Metastasis 12/2023 - 09/2012
2	Stomach Neoplasms (Stomach Cancer) 02/2023 - 11/2020
2	Hyperphosphatemia 02/2023 - 01/2023
2	Prostatic Neoplasms (Prostate Cancer) 10/2022 - 10/2020
2	Nausea 10/2022 - 01/2022
2	Fever (Fevers) 09/2022 - 04/2014
2	Acinar Cell Carcinoma 01/2021 - 11/2009
2	Epithelioid Hemangioendothelioma 01/2021 - 10/2018
2	Ascites 01/2021 - 12/2007
2	Hepatitis 01/2019 - 09/2012
2	Anorexia 01/2019 - 10/2014
2	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 08/2015 - 04/2010
2	Drug-Related Side Effects and Adverse Reactions 10/2014 - 10/2012
2	Interstitial Lung Diseases (Interstitial Lung Disease) 12/2012 - 08/2010
2	Pneumonia (Pneumonitis) 10/2012 - 01/2009

Drug/Important Bio-Agent (IBA)

41	Gemcitabine FDA Link 08/2023 - 01/2005
26	Cisplatin (Platino)FDA LinkGeneric 08/2023 - 01/2003
12	PlatinumIBA 05/2024 - 08/2015
8	Sorafenib (BAY 43-9006)FDA Link 10/2020 - 03/2010
8	Fluorouracil (Carac)FDA LinkGeneric 06/2017 - 01/2003
7	Biomarkers (Surrogate Marker)IBA 01/2024 - 10/2013
7	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2023 - 02/2005
6	Irinotecan (Camptosar)FDA LinkGeneric 10/2022 - 01/2008
5	C-Reactive ProteinIBA 12/2023 - 01/2009
5	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 09/2012
5	Alanine Transaminase (SGPT)IBA 06/2017 - 02/2005
4	EnzymesIBA 05/2024 - 09/2004
4	folfirinoxIBA 08/2022 - 02/2015
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 09/2012
4	TegafurIBA 03/2011 - 08/2005
4	Epirubicin (Ellence)FDA LinkGeneric 07/2008 - 01/2003
3	Carcinoembryonic AntigenIBA 12/2023 - 09/2004
3	Type 2 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 2)IBA 01/2023 - 01/2021
3	Oxaliplatin (Eloxatin)FDA LinkGeneric 10/2022 - 10/2020
3	Etoposide (VP 16)FDA LinkGeneric 10/2022 - 04/2010
3	Streptozocin (Streptozotocin)FDA Link 01/2022 - 07/2015
3	Protein Subunit VaccinesIBA 01/2021 - 12/2010
3	Peptides (Polypeptides)IBA 01/2021 - 12/2009
3	Mitoxantrone (Novantrone)FDA LinkGeneric 06/2017 - 02/2005
3	orantinib (SU6668)IBA 10/2014 - 02/2011
3	UracilIBA 03/2011 - 08/2005
2	Immune Checkpoint InhibitorsIBA 05/2024 - 01/2019
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 04/2024 - 02/2017
2	CarbohydratesIBA 12/2023 - 09/2004
2	AntigensIBA 12/2023 - 09/2004
2	futibatinibIBA 02/2023 - 01/2023
2	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 02/2023 - 02/2011
2	SteroidsIBA 09/2022 - 10/2020
2	Bevacizumab (Avastin)FDA Link 09/2022 - 08/2018
2	Everolimus FDA Link 11/2021 - 10/2012
2	Histone Deacetylase InhibitorsIBA 01/2021 - 01/2019
2	VaccinesIBA 01/2021 - 01/2011
2	resminostatIBA 01/2021 - 01/2019
2	GlypicansIBA 01/2021 - 04/2014
2	Circulating Tumor DNAIBA 12/2020 - 12/2015
2	regorafenibIBA 10/2020 - 02/2018
2	Cytotoxins (Cytolysins)IBA 07/2020 - 08/2015
2	Sunitinib (Sutent)FDA Link 06/2019 - 10/2013
2	Amylases FDA Link 01/2019 - 03/2014
2	Indicators and Reagents (Reagents)IBA 10/2018 - 01/2016
2	trametinibIBA 08/2018 - 01/2018
2	N-formylmethionylphenylalanine (FMP)IBA 06/2017 - 02/2005
2	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA 10/2014 - 02/2011
2	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 10/2014 - 02/2011
2	Angiogenesis InhibitorsIBA 10/2014 - 02/2011
2	Tyrosine Kinase InhibitorsIBA 09/2012 - 02/2011
2	alpha-Fetoproteins (alpha-Fetoprotein)IBA 09/2012 - 10/2006
2	S 1 (combination)IBA 04/2012 - 12/2010
2	HLA Antigens (Human Leukocyte Antigens)IBA 01/2011 - 12/2010

Therapy/Procedure

67	Drug Therapy (Chemotherapy) 05/2024 - 01/2005
40	Therapeutics 04/2023 - 01/2005
9	Combination Drug Therapy (Combination Chemotherapy) 02/2022 - 01/2005
8	Stents 03/2024 - 09/2020
4	Radiotherapy 02/2024 - 01/2005
4	Self Expandable Metallic Stents 12/2023 - 04/2022
2	Choledochostomy 09/2023 - 04/2022
2	Precision Medicine 04/2023 - 06/2020
2	Punctures 03/2023 - 01/2023
2	Oral Administration 02/2016 - 04/2014
2	Chemoradiotherapy 12/2012 - 01/2005